The conjunction and unification in between multidisciplinarity research approaches and the Indian Knowledge System (IKS) is synthesized in the form contemporary research evidences. To address complex, real-world problems in health, agriculture, environment, and education, multi-disciplinarity plays a significant role in bringing different perspectives of multiple disciplines together. IKS provide knowledge derived from experience, observation, and experimentation which has been generated and collected from many centuries in the form of indigenous religious and cultural practices, in literatures (oral traditions, stories, and folklore), and other institutional practices (such as traditional medicine, sustainable agriculture, environmental management, craft skills, community laws, governance structures, beliefs, rituals, and social customs). The present systematic review or meta-analysis locates and evaluates studies that have combined IKS and modern disciplinary methods, identifies the methodological and epistemological challenges that arise in such integration, and proposes pragmatic frameworks andresearch designs for rigorous interdisciplinary inquiry. Priority wise key core and major strategic areas, considered in the present study include: health - where ayurveda and modern medicine link and affiliates in the form of clinical trials and pharmacological studies; empirically evaluated sustainable agriculture traditional practices like crop diversity, natural farming, indigenous water management; Vedic and

classical mathematical procedures and observational astronomy which crossroads IKS with Science, Technology, Engineering, Mathematics (STEM) with translational research implications; and finally promotion of IKS in all stages of school as well as in higher education which can be achieved via pedagogy and curricular reforms as per the National Education Policy 2020 (NEP-2020). The present review study gives importance to protocols which are evidence-based, community led development of knowledge, and role of domain experts, social and arts-aesthetic scientists and finally methodologists in bridging the gaps of IKS with authenticity. Mismatch in standards, incomplete and improper documentation and ethical concerns are some of the main issues and stumbling blocks which are dealt in the present study with specific actions, practical measures, and tangible steps to mitigate the same while maintaining and preserving cultural heritage and ethnic integrity. Present study culminates and reckons that with the help of meticulous, precise, and scientific stringency and native epistemic multi-disciplinary studies and research, can expand knowledge frontiers and produce socially relevant innovations; however, success requires methodological reflexivity, transparent reporting, and capacity-building at institutional levels.